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Category: Hardware & Devices, Home & Family, Productivity & Work, Operating Systems Category: Operating systemMolecular biology of astrocytomas. The development of astrocytoma in humans may involve genetic and/or epigenetic alterations. However, the molecular mechanisms that lead to astrocytoma development remain largely unknown. To understand better the pathogenesis of astrocytoma, the most common type of primary brain tumor, the authors determined the presence and molecular characterization of the t(11;14) translocation in 29 human astrocytomas. To analyze the 11q14-q23 region, the authors used Southern hybridization, fluorescence in situ hybridization (FISH), and oligonucleotide-based microarrays. In addition, the authors analyzed the methylation status of the promoter regions of selected tumor suppressor genes. The presence of a translocation t(11;14) was confirmed in 23 astrocytomas, and all of these tumors had a characteristic G-C oligonucleotide content. One astrocytoma had a t(12;14) and another had a t(14;22). The presence of a translocation was positively correlated with grade (less differentiated astrocytoma > anaplastic astrocytoma). As the 11q13.3-q14.1 region, which contains the CHOP gene, has been implicated in the development of a variety of human tumors, the authors also examined its methylation status in astrocytomas. Promoter hypermethylation was associated with the presence of the translocation. The data suggest that the t(11;14) translocation, in conjunction with gene methylation, may play a role in the pathogenesis of astrocytomas.Q: Efficient way to get a hash out of an array In a script I'm doing in Perl, I have an array @out that has been generated by a subroutine. sub generate_out { my @out = (); foreach $item (@input) { my @a = @$item; @out = ("a" x @a); } return @out; } I want to get a hash out of it. I've done it before in






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